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The Jaschke Lab bridges the fields of Synthetic Biology, Microbiology, Virology, and Systems Biology to address fundamental problems of:
(1) how do we discover all the components necessary to make a functional genome? (2) how do we reconfigure these components to make engineered genetic systems more reliable, more predictable, and more useful? (3) how do we engineer biology to benefit human health and reduce impacts on our environment? |
We aim to answer important questions by pioneering the science and engineering of synthetic genomes by designing, building, testing, and learning from our designs.
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News
Jan 2025
• Won project funding and PhD scholarships (to be advertised soon) for two MQ BioInnovation projects: (1) Designing RNA with Custom
Properties using AI, and (2) Towards Total Digital Control of Biological Systems.
• Sanila Asad successful completed her MRes degree. Congratulations Sanila!
• Dominic Scopelliti successfully completed his PhD defence. Congratulations Dominic!
Nov 2024
• Paper accepted. Pamela's first published paper (and first authorship) and Russel's third from his PhD work. Congratulations!
Tsoumbris, P., Vincent, R. & Jaschke, P.R. Designing a simple and efficient phage biocontainment system using the amber suppressor initiator tRNA. Arch Virol 169, 248 (2024). https://doi.org/10.1007/s00705-024-06170-9
• Project pitch on creating a novel translation system dependent on light won the people's choice award at the MQ BioInnovation Initiative Workshop!
Oct 2024
• Natalie Roberts submitted her MRes thesis entitled "Investigating Lysis Inhibition in a Novel T4-like Phage" for examination. Good luck Natalie!
Sept 2024
• Dominic Scopelliti submitted his PhD thesis entitled "Creating a library of initiator tRNA mutants to initiate protein translation from reprogrammed sense codons" for examination. Good luck Dominic!
• Sanila Asad submitted her MRes thesis entitled "Identification and comparative genomics of phage that
productively infect L-form Escherichia coli" for examination. Good luck Sanila!
July 2024
• Ruby Westerman has joined the lab to do her MRes research project on developing a new phage display system. Welcome Ruby!
• Viruses of Microbes (VoM) in Cairns, Australia was a huge success! The lab presented posters and we all made connections with amazing scientists from around the world.
June 2024
• New paper published! Congratulations Ellina, Dominic, and Hannah!
Asgharzadeh Kangachar, S., Logel, D.Y., Trofimova, E., Zhu, H.X., Zaugg, J., Schembri, M.A., Weynberg, K.D., Jaschke, P.R., 2024. Discovery and characterisation of new phage targeting uropathogenic Escherichia coli. Virology 597, 110148. https://doi.org/10.1016/j.virol.2024.110148
• Grant Success! MQ-Mahidol University Joint Research Seeding Grant with Mullika Chomnawang
Mar 2024
• New book chapter published! Congratulations Ellina and Dominic.
Trofimova, E., Logel, D.Y., Jaschke, P.R. (2024). An Improved Method for Eliminating or Creating Intragenic Bacterial Promoters. In: Braman, J.C. (eds) Synthetic Biology. Methods in Molecular Biology, vol 2760. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3658-9_12
Jan 2024
• Natalie Roberts has joined the lab to do her MRes research project. Welcome Natalie!
• New paper published!
Ghaly, T.M., Focardi, A., Elbourne, L.D.H., Sutcliffe B, Humphreys WF, Jaschke PR, Tetu SG, Paulsen IT. Exploring virus-host-environment interactions in a chemotrophic-based underground estuary. Environmental Microbiome 19, 9 (2024). https://doi.org/10.1186/s40793-024-00549-6
• New pre-print posted to bioRxiv:
Shahla Asgharzadeh Kangachar, Dominic Y Logel, Ellina Trofimova, Hannah X Zhu, Julian Zaugg, Mark A Schembri, Karen D Weynberg, Paul R Jaschke. (2024). Discovery and characterisation of new phage targeting uropathogenic Escherichia coli. DOI: https://doi.org/10.1101/2024.01.12.575291
• Grant success to get badly needed equipment & infrastructure:
- MQRIS S 24: High throughput Phenotyping Platform for Galleria Research Facility
- MQRIS L 24: Innovative platform for high-throughput colorimetric assays and cell phenotyping
- MQRIS L 24: Large-volume Ultra and High-speed centrifuges
Dec 2023
• Andy has passed his thesis examination, congratulations Dr. Hutvagner!
• Dr. Dominic Logel has joined the lab again to work on a phage display project. Welc
• Won project funding and PhD scholarships (to be advertised soon) for two MQ BioInnovation projects: (1) Designing RNA with Custom
Properties using AI, and (2) Towards Total Digital Control of Biological Systems.
• Sanila Asad successful completed her MRes degree. Congratulations Sanila!
• Dominic Scopelliti successfully completed his PhD defence. Congratulations Dominic!
Nov 2024
• Paper accepted. Pamela's first published paper (and first authorship) and Russel's third from his PhD work. Congratulations!
Tsoumbris, P., Vincent, R. & Jaschke, P.R. Designing a simple and efficient phage biocontainment system using the amber suppressor initiator tRNA. Arch Virol 169, 248 (2024). https://doi.org/10.1007/s00705-024-06170-9
• Project pitch on creating a novel translation system dependent on light won the people's choice award at the MQ BioInnovation Initiative Workshop!
Oct 2024
• Natalie Roberts submitted her MRes thesis entitled "Investigating Lysis Inhibition in a Novel T4-like Phage" for examination. Good luck Natalie!
Sept 2024
• Dominic Scopelliti submitted his PhD thesis entitled "Creating a library of initiator tRNA mutants to initiate protein translation from reprogrammed sense codons" for examination. Good luck Dominic!
• Sanila Asad submitted her MRes thesis entitled "Identification and comparative genomics of phage that
productively infect L-form Escherichia coli" for examination. Good luck Sanila!
July 2024
• Ruby Westerman has joined the lab to do her MRes research project on developing a new phage display system. Welcome Ruby!
• Viruses of Microbes (VoM) in Cairns, Australia was a huge success! The lab presented posters and we all made connections with amazing scientists from around the world.
June 2024
• New paper published! Congratulations Ellina, Dominic, and Hannah!
Asgharzadeh Kangachar, S., Logel, D.Y., Trofimova, E., Zhu, H.X., Zaugg, J., Schembri, M.A., Weynberg, K.D., Jaschke, P.R., 2024. Discovery and characterisation of new phage targeting uropathogenic Escherichia coli. Virology 597, 110148. https://doi.org/10.1016/j.virol.2024.110148
• Grant Success! MQ-Mahidol University Joint Research Seeding Grant with Mullika Chomnawang
Mar 2024
• New book chapter published! Congratulations Ellina and Dominic.
Trofimova, E., Logel, D.Y., Jaschke, P.R. (2024). An Improved Method for Eliminating or Creating Intragenic Bacterial Promoters. In: Braman, J.C. (eds) Synthetic Biology. Methods in Molecular Biology, vol 2760. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3658-9_12
Jan 2024
• Natalie Roberts has joined the lab to do her MRes research project. Welcome Natalie!
• New paper published!
Ghaly, T.M., Focardi, A., Elbourne, L.D.H., Sutcliffe B, Humphreys WF, Jaschke PR, Tetu SG, Paulsen IT. Exploring virus-host-environment interactions in a chemotrophic-based underground estuary. Environmental Microbiome 19, 9 (2024). https://doi.org/10.1186/s40793-024-00549-6
• New pre-print posted to bioRxiv:
Shahla Asgharzadeh Kangachar, Dominic Y Logel, Ellina Trofimova, Hannah X Zhu, Julian Zaugg, Mark A Schembri, Karen D Weynberg, Paul R Jaschke. (2024). Discovery and characterisation of new phage targeting uropathogenic Escherichia coli. DOI: https://doi.org/10.1101/2024.01.12.575291
• Grant success to get badly needed equipment & infrastructure:
- MQRIS S 24: High throughput Phenotyping Platform for Galleria Research Facility
- MQRIS L 24: Innovative platform for high-throughput colorimetric assays and cell phenotyping
- MQRIS L 24: Large-volume Ultra and High-speed centrifuges
Dec 2023
• Andy has passed his thesis examination, congratulations Dr. Hutvagner!
• Dr. Dominic Logel has joined the lab again to work on a phage display project. Welc
