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Dr. Paul Jaschke
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Current Lab Members
Higher-Degree Research Students
Hannah Zhu - PhD Student (May 2021 - Current)
Masters of Research, Molecular Sciences, Macquarie University (2020)
B.Sc. in Medical Sciences, Macquarie University (2018)
Project: My project is focusing on establishing a high-throughput synthetic biology pipeline for the rational design and synthesis of novel phages to be used as therapeutic treatment of antibiotic resistant pathogens. Specifically, I am targeting multidrug resistant uropathogenic E. coli (UPEC) that is a common cause of acute, chronic, and recurrent urinary tract infections. I aim for generating a diverse library of UPEC-targeting phages with improved performance and efficacy, using the proposed phage engineering pipeline.
Masters of Research, Molecular Sciences, Macquarie University (2020)
B.Sc. in Medical Sciences, Macquarie University (2018)
Project: My project is focusing on establishing a high-throughput synthetic biology pipeline for the rational design and synthesis of novel phages to be used as therapeutic treatment of antibiotic resistant pathogens. Specifically, I am targeting multidrug resistant uropathogenic E. coli (UPEC) that is a common cause of acute, chronic, and recurrent urinary tract infections. I aim for generating a diverse library of UPEC-targeting phages with improved performance and efficacy, using the proposed phage engineering pipeline.
Pamela Tsoumbris - MRes Student (July 2020 - Current)
Masters of Research, Molecular Sciences, Macquarie University (2021)
B.Sc. in Molecular Molecular Biology and Genetics, The University of Sydney (2018)
Masters of Research, Molecular Sciences, Macquarie University (2021)
B.Sc. in Molecular Molecular Biology and Genetics, The University of Sydney (2018)
Dominic Scopelliti - PhD Student (Feb 2020 - Current)
BMedScs, Macquarie University (2018)
Masters of Research, Molecular Sciences, Macquarie University (2019)
Project: I am currently interested in utilising mass spectrometry to characterise proteins expressed using an orthogonal translation initiation system in E. coli. It is my goal to improve our understanding of how the use of an orthogonal system may impact protein expression and to explore its potential applications in synthetic biology.
BMedScs, Macquarie University (2018)
Masters of Research, Molecular Sciences, Macquarie University (2019)
Project: I am currently interested in utilising mass spectrometry to characterise proteins expressed using an orthogonal translation initiation system in E. coli. It is my goal to improve our understanding of how the use of an orthogonal system may impact protein expression and to explore its potential applications in synthetic biology.
Ellina Trofimova - Masters of Research Student (Jan 2020 - Current)
B.Sc. in Molecular Sciences, Macquarie University (2018)
B.Sc. in Molecular Sciences, Macquarie University (2018)
Andy Hutvagner - PhD Student (Jan 2019 - Current)
B.Sc. in Molecular Sciences, Macquarie University (2017)
Masters of Research, Molecular Sciences, Macquarie University (2019)
Project
I’m am currently working on engineering new ways to initiate and control the translation of desirable proteins in E.coli. Ultimately, I aim for this to contribute new mechanisms towards the development of an orthogonal central dogma: a new and improved system which scientists can utilise to enhance their designs in synthetic biology.
B.Sc. in Molecular Sciences, Macquarie University (2017)
Masters of Research, Molecular Sciences, Macquarie University (2019)
Project
I’m am currently working on engineering new ways to initiate and control the translation of desirable proteins in E.coli. Ultimately, I aim for this to contribute new mechanisms towards the development of an orthogonal central dogma: a new and improved system which scientists can utilise to enhance their designs in synthetic biology.
Russel Vincent - PhD student (Jan 2018 - Current)
B.Sc. (Honors) in Microbiology, St. Xavier’s College, Kolkata (India) (2016)
Masters of Research, Molecular Sciences, Macquarie University (2018)
Project
My work is focusing on the intersection of protein translation and start codons. Recently it was discovered that many previously unrecognised codons are able to initiate translation in E. coli and I am characterising this phenomena more fully while looking at potential applications in synthetic biology.
B.Sc. (Honors) in Microbiology, St. Xavier’s College, Kolkata (India) (2016)
Masters of Research, Molecular Sciences, Macquarie University (2018)
Project
My work is focusing on the intersection of protein translation and start codons. Recently it was discovered that many previously unrecognised codons are able to initiate translation in E. coli and I am characterising this phenomena more fully while looking at potential applications in synthetic biology.
Bradley Wright - PhD student (Sept 2016 - Current)
B.Sc, University of Technology Sydney (2013)
Masters of Research, Molecular Sciences, Macquarie University (2015)
Project: I am currently interested in applying proteomics to the study of engineered biological systems. I hope to gain insight to how these systems operate at the proteome level as well as guide the design process that will ultimately lead us to better understanding how we can produce more efficient designs.
B.Sc, University of Technology Sydney (2013)
Masters of Research, Molecular Sciences, Macquarie University (2015)
Project: I am currently interested in applying proteomics to the study of engineered biological systems. I hope to gain insight to how these systems operate at the proteome level as well as guide the design process that will ultimately lead us to better understanding how we can produce more efficient designs.
Dominic Logel - PhD student (July 2016 - Current)
B.Sc, Biomolecular Sciences (Macquarie University)
M.Res, Structural Biology (Macquarie University)
Project
My project is attempting to determine the role of synthetic regulation and gene essentiality on a whole viral genome by deep characterisation on the changes that ensue from each genomic design synthesised. By addressing these parameters, genomic design criteria can be elucidated so as to catalogue what changes can be made to a whole genome, whilst maintaining or improving organism survival and replication. The results from this project will also determine the degree from which an organisms regulation and genome organisation can be divorced from nature so as to synthesise increasingly rational organisms.
B.Sc, Biomolecular Sciences (Macquarie University)
M.Res, Structural Biology (Macquarie University)
Project
My project is attempting to determine the role of synthetic regulation and gene essentiality on a whole viral genome by deep characterisation on the changes that ensue from each genomic design synthesised. By addressing these parameters, genomic design criteria can be elucidated so as to catalogue what changes can be made to a whole genome, whilst maintaining or improving organism survival and replication. The results from this project will also determine the degree from which an organisms regulation and genome organisation can be divorced from nature so as to synthesise increasingly rational organisms.
Lab Alumni
Macquarie University
Dr. Bradley Wright
• Postdoctoral Researcher in Jin Chen's lab at UT Southwestern Medical Center
Amy Callaghan
• Scientific Officer at Laverty Pathology
Karl Myers
• Legal Intern, Amgen
Nicolas Aryanpour
• PhD student Louvain-la-Neuve, Belgium
Pandelitsa (Zoe) Yiasemides
• Laverty Pathology
• MQ Department of Molecular Sciences Summer Vacation Scholarship Student (2018)
• Postdoctoral Researcher in Jin Chen's lab at UT Southwestern Medical Center
Amy Callaghan
• Scientific Officer at Laverty Pathology
Karl Myers
• Legal Intern, Amgen
Nicolas Aryanpour
• PhD student Louvain-la-Neuve, Belgium
Pandelitsa (Zoe) Yiasemides
• Laverty Pathology
• MQ Department of Molecular Sciences Summer Vacation Scholarship Student (2018)
Stanford University
Gabrielle Dotson
• Ph.D. Candidate at University of Michigan - Department of Computational Medicine & Bioinformatics
• Bioengineering undergrad, Stanford University
Kay Hung
• General Surgery Resident, Stanford Medicine, Stanford University
• Bioengineering undergrad, Stanford University
Erica Lieberman
• Eligo Bioscience
• Bioengineering undergrad, Stanford University
Diane Liu
• Software Engineering at Gusto
Jon Rodriguez
• Chief Scientist/Founder of Epiphany Eyewear/Vergence Labs acquired by Snapchat
Adrian Sierra
• Computer Scientist working for Adobe Systems, San Jose
• Ph.D. Candidate at University of Michigan - Department of Computational Medicine & Bioinformatics
• Bioengineering undergrad, Stanford University
Kay Hung
• General Surgery Resident, Stanford Medicine, Stanford University
• Bioengineering undergrad, Stanford University
Erica Lieberman
• Eligo Bioscience
• Bioengineering undergrad, Stanford University
Diane Liu
• Software Engineering at Gusto
Jon Rodriguez
• Chief Scientist/Founder of Epiphany Eyewear/Vergence Labs acquired by Snapchat
Adrian Sierra
• Computer Scientist working for Adobe Systems, San Jose
The University of British Columbia
Amelia Hardjasa
• Data Analyst at EnerNOC, Vancouver
Tobie Patterson
• Analyst, Public Health Initiatives at Fraser Health Authority,
Elizabeth Digby
• Medical School at the University of Calgary
Connie Lee
• Physiotherapy in Victoria
• Data Analyst at EnerNOC, Vancouver
Tobie Patterson
• Analyst, Public Health Initiatives at Fraser Health Authority,
Elizabeth Digby
• Medical School at the University of Calgary
Connie Lee
• Physiotherapy in Victoria
