Jaschke Lab
  • Home
  • Research
  • Publications
  • People
  • Teaching
    • Macquarie University
    • BioCurious
    • Zamorano
  • Contact
  • Links
  • Opportunities
  • NIPG Postdoc
  • AI PhD
  • Home
  • Research
  • Publications
  • People
  • Teaching
    • Macquarie University
    • BioCurious
    • Zamorano
  • Contact
  • Links
  • Opportunities
  • NIPG Postdoc
  • AI PhD
Picture

Picture

Dr. Paul Jaschke
Senior Lecturer (equiv. Associate Professor) in Synthetic Biology
School of Natural Sciences, Macquarie University

Education
Postdoctoral Fellow, Bioengineering, Stanford University (2015)
Ph.D. Microbiology & Immunology, The University of British Columbia (2010)
B.Sc. (Honours) Biochemistry, The University of Alberta (2002)

​CV

ORCiD: orcid.org/0000-0003-2359-1301
​
​
My Other Profiles
Research Gate Profile
LinkedIn Profile
Academia.edu Profile
Twitter
Mendeley Profile
Google Scholar Profile
OpenWetWare

***Your name here***

Are you curious about synthetic biology and pushing the limits of genetic system design? 
​I am always looking for the right graduate level (HDR) students to join the lab.  Masters of Research and PhD scholarships may be available for candidates who have published in international journals and received awards. If you are interested please forward a copy of your CV to [email protected]

Current Lab Members

Higher-Degree Research Students

Picture
Natalie Roberts - MRes Student (Jan 2024 - Current)
Western Sydney University Bachelor of Science (Advanced Science) (2022)

​Project:
I am working with Pamela to use Synthetic Biology to engineer bacteriophage to lyse uropathogenic E. coli L-form (cell-wall deficient) bacteria. L-form bacteria are typically resistant to phage infection and clinically relevant antibiotics and may also have a role in recurrent bacterial infections. In this research, I aim to determine which genes are involved in pseudolysogeny (i.e., the inability of phage to lyse their bacterial host) and how phage deficient in these genes shape up against L-form bacteria.

Picture
Sanila Asad - MRes Student (Aug 2022 - Current)
Graduate Diploma, Infection and Immunity, The University of Sydney (2019)
B.Sc. (honours) in Biotechnology,
Forman Christian College (2014)

​Project: My project is focused on understanding why some bacteriophage can infect slow growing cells with altered membrane (called L-form) and some cannot
. The results of this work will inform our choices of phage used in phage therapy and in combination antibiotic/phage therapy.

Picture
Hannah Zhu - PhD Student (May 2021 - Current)
Masters of Research, Molecular Sciences, Macquarie University (2020)
B.Sc. in Medical Sciences, Macquarie University (2018)

​Project: 
My project is focusing on establishing a high-throughput synthetic biology pipeline for the rational design and synthesis of novel phages to be used as therapeutic treatment of antibiotic resistant pathogens. Specifically, I am targeting multidrug resistant uropathogenic E. coli (UPEC) that is a common cause of acute, chronic, and recurrent urinary tract infections. I aim for generating a diverse library of UPEC-targeting phages with improved performance and efficacy, using the proposed phage engineering pipeline.

Picture
Pamela Tsoumbris - Ph.D. Student (Oct 2021 - Current)
​B.Sc. in Molecular Molecular Biology and Genetics, The University of Sydney (2018)
MRes in Molecular Sciences, Macquarie University (2021)

Project: I am currently interested in harnessing synthetic biology to engineer bacteriophage to become more efficient at lysing atypical bacterial infections. In doing so, I hope to broaden our understanding of phage interactions with bacterial hosts – specifically in the context of uropathogenic E. coli.​

Picture
Dominic Scopelliti - PhD Student (Feb 2020 - Current)
BMedScs, Macquarie University (2018)
Masters of Research, Molecular Sciences, Macquarie University (2019)

Project
: 
I am currently interested in utilising mass spectrometry to characterise proteins expressed using an orthogonal translation initiation system in E. coli.  It is my goal to improve our understanding of how the use of an orthogonal system may impact protein expression and to explore its potential applications in synthetic biology. 

Picture
Ellina Trofimova - Ph.D. Student (Feb 2022 - Current)
MRes in Molecular Sciences, Macquarie University (2021)
MSc in Chemical and Molecular Sciences, Macquarie University (2019)


Project: My project is focused on engineering icosahedral bacteriophages to extend their bacterial host range. Additionally, I use bioinformatics to understand the genetic determinants of phage infection. Altogether, my research is aimed to broaden the fundamental knowledge of the bacteriophage infection process to create more efficient treatments with phage therapy..​​

Lab Alumni

Macquarie University

Dr. Andy Hutvagner (completed PhD 2023)
• Research Scientist at EnGeneIC

Kein Huynh (completed MRes 2022)
• Compounding Assistant (Baxter Healthcare)

Dr. Russel Vincent (completed MRes 2017; PhD 2021)
• 
Postdoctoral Researcher in George Church's lab at Harvard Medical School

Dr. Dominic Y. Logel (completed PhD 2020)
• Fermentation scientist at Hydgene Renewables 
​
Dr. Bradley Wright (completed PhD 2020)
• 
Postdoctoral Associate in the Wilusz Lab at Baylor College of Medicine 

Amy Callaghan
• Scientific Officer at Laverty Pathology

Karl Myers
• Lawyer at Meridian Lawyers

Nicolas Aryanpour
• PhD student Université Catholique de Louvain, Belgium

Pandelitsa (Zoe) Yiasemides
• Scientific Officer at Laverty Pathology
​• MQ Department of Molecular Sciences Summer Vacation Scholarship Student (2018)

Stanford University

Gabrielle Dotson
• Bioinformatician at bit.bio
• Ph.D. Candidate at University of Michigan - Department of Computational Medicine & Bioinformatics
• Bioengineering undergrad, Stanford University

Kay Hung
• General Surgery Resident, Stanford Medicine, Stanford University
​• Bioengineering undergrad, Stanford University

Erica Lieberman
• Discovery and Automation Team Lead at Eligo Bioscience
• Bioengineering undergrad, Stanford University

Diane Liu
• Engineering Manager at Path

Jon Rodriguez
• Chairman & Chief Product Officer at preamble
• Chief Scientist/Founder of Epiphany Eyewear/Vergence Labs acquired by Snapchat 

Adrian Sierra
• Software Engineer at Adobe

The University of British Columbia

Amelia Hardjasa
• Data Analyst at EnerNOC, Vancouver, Canada

Tobie Patterson
• Analyst, Public Health Initiatives at Fraser Health Authority, Canada

Elizabeth Digby
• Medical School at the University of Calgary, AB, Canada

Connie Lee
• Physiotherapy in Victoria, BC, Canada
Powered by Create your own unique website with customizable templates.